The reference site for Cyproheptadine

Cyproheptadine (/ˌsaɪproʊˈhɛptədiːn/), sold under the brand name Periactin or Peritol, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.


Cyproheptadine is an antihistamine. Cyproheptadine blocks the effects of the naturally occurring chemical histamine in your body.

Cyproheptadine is used to treat sneezing, runny nose, itchy and watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.


Brand Name(s): Periactin
CAS nº: 129-03-3
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Product Info

The sections below will provide you with more specific information and guidelines related to cyproheptadine and its correct use. Please read them carefully.

FDA Information

Cyproheptadine has been approved by the US Food and Drug Administration. However, there is only one drug available over the counter which contains cyproheptadine. It is the anti-allergy drug Periactin®, also used to treat migraine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Cyproheptadine is an antihistamine. This particular medicine works by blocking the effects of the naturally occurring chemical histamine in your body.

Cyproheptadine is used to treat sneezing, runny nose, itchy and watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.

Other uses for this medicine

Cyproheptadine may also be used for a hormone disorder (Cushing’s Syndrome), and sexual function problems due to certain drugs.

Additionally, although not approved by the FDA for this purpose, cyproheptadine has been used to stimulate appetite in underweight patients (anorexia nervosa).

Cyproheptadine is also used, though rarely, as a prophylactic drug for migraine.

Nevertheless, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Cyproheptadine comes as tablets and a liquid form to be taken orally. It is usually taken two or three times a day.

Take cyproheptadine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water, and either with or without food.

To ensure that you get a correct dose, measure the syrup form of cyproheptadine with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

It is important that you never take more medication than what has been prescribed to you. The maximum amount of cyproheptadine that you should take in 1 day is 32 mg.

What special precautions should I follow?


Please inform your doctor if you are taking any of the following medicines: anxiety or sleep medicines such as alprazolam (Xanax®), diazepam (Valium®), chlordiazepoxide (Librium®), temazepam (Restoril®), or triazolam (Halcion®); medications for depression such as amitriptyline (Elavil®), doxepin (Sinequan®), nortriptyline (Pamelor®), fluoxetine (Prozac®), sertraline (Zoloft®), or paroxetine (Paxil®); or any other medications that make you feel drowsy, sleepy, or relaxed.

Drugs other than those listed here may also interact with cyproheptadine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. So too, do not take cyproheptadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan®), phenelzine (Nardil®), or tranylcypromine (Parnate®) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Furthermore, tell your doctor if you have glaucoma or increased pressure in the eye, a stomach ulcer, an enlarged prostate, bladder problems, or difficulty urinating, an overactive thyroid (hyperthyroidism), hypertension or any type of heart problems, or asthma. You may not be able to take cyproheptadine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Cyproheptadine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take cyproheptadine without first talking to your doctor if you are pregnant.

Additionally, cyproheptadine passes into breast milk. Infants are especially sensitive to the effects of antihistamines, and serious side effects could occur in a nursing baby. Cyproheptadine is not recommended if you are breast-feeding a baby. Do not take cyproheptadine without first talking to your doctor if you are nursing a baby.

If you are over 60 years of age, you may be more likely to experience side effects from cyproheptadine. You may require a lower dose of this medication.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Cyproheptadine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

The consumption of alcohol may also increase these symptoms.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose.

Do not take a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

Stop taking cyproheptadine and seek emergency medical attention if you experience:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)

Other, less serious side effects may be more likely to occur. Continue to take cyproheptadine and talk to your doctor if you experience:

sleepiness, fatigue, or dizziness
dry mouth
difficulty urinating or an enlarged prostate

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed and, if required, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. If the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

extreme sleepiness
ringing in the ears
blurred vision
large pupils
dry mouth
possibly seizures

Product Images


Below you will find images and specific information on the principal types of cyproheptadine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 4 MG
Imprint: PAR 043

Strength(s): 4 MG
Imprint: PLIVA 314
Manufacturer: PLIVA INC.

Strength(s): 4 MG
Imprint: Z 2929
Manufacturer: ZENITH

Strength(s): 4 MG
Imprint: PERIACTIN | MSD 62

Strength(s): 2 MG / 5 ML
Imprint: Cyproheptadine Hydrochloride Syrup
Manufacturer: ACTAVIS

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